abstract：:Local treatment of rat peripheral nerves with capsaicin induces permanent impairment of afferent C-fiber functions and changes in the response properties of spinal dorsal horn neurons. In this study a new experimental approach, the "capsaicin gap" technique, has been utilized in an attempt to unravel pathomorphologica...

journal_title：Neuroscience

authors： Jancsó G,Lawson SN

更新日期：1990-01-01 00:00:00

abstract：:Using arsenazo III as an intracellular indicator to monitor the calcium transients elicited by voltage-clamp depolarizing pulse, the effect of prolonged in vitro lithium treatment on excitation--contraction coupling in frog twitch muscle fibres was investigated. Incubation in 10 mM Li+ Ringer's solution for 2 days cau...

journal_title：Neuroscience

authors： Zhu PH,Fu DX

更新日期：1990-01-01 00:00:00

abstract：:Reflex response of fusimotoneurons to sinusoidal muscle stretching were investigated in decerebrated cats. Nerve impulses of single fusimotoneurons were recorded from thin filaments dissected from otherwise intact nerves to triceps surae muscles. Amplitude of the sinusoidal stretching of these muscles was 3 mm peak-to...

journal_title：Neuroscience

authors： Anastasijević R,Jovanović K,Vuco J

更新日期：1990-01-01 00:00:00

abstract：:Antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediation of nausea and vomiting. We have used autoradiography to examine the...

journal_title：Neuroscience

authors： Leslie RA,Reynolds DJ,Andrews PL,Grahame-Smith DG,Davis CJ,Harvey JM

更新日期：1990-01-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor antagonist 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid and the non-N-methyl-D-aspartate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione have been iontophoretically applied to cells in the cat dorsal lateral geniculate nucleus and their effects on the visual re...

journal_title：Neuroscience

authors： Sillito AM,Murphy PC,Salt TE

更新日期：1990-01-01 00:00:00

abstract：:The aim of this study was to assess whether omega conotoxin fraction GVIA, a potent blocker of N- and L-type voltage-sensitive calcium channels, might interfere with reflex responses (micturition, blood pressure rise in spinal rats) produced by activation of capsaicin-sensitive sensory nerves of the rat urinary bladde...

journal_title：Neuroscience

authors： Maggi CA,Giuliani S,Santicioli P,Tramontana M,Meli A

更新日期：1990-01-01 00:00:00

abstract：:Previous research has implicated hippocampal rhythmical slow activity in the mechanisms of action of the anxiolytic drugs. In this study ethanol and a putative ethanol antagonist, Ro 15-4513, were investigated with reticular elicitation of rhythmical slow activity. Doses of ethanol between 0.6 and 3.1 g/kg were used. ...

journal_title：Neuroscience

authors： Coop CF,McNaughton N,Warnock K,Laverty R

更新日期：1990-01-01 00:00:00

abstract：:Clinical and experimental evidence indicates that exposure to alcohol in utero is associated with altered immune capacity. The mechanisms underlying such abnormalities are not clear. However, the suggestion that reciprocal interactions between the immune and the nervous systems are necessary for a competent immune res...

journal_title：Neuroscience

authors： Gottesfeld Z,Christie R,Felten DL,LeGrue SJ

更新日期：1990-01-01 00:00:00

abstract：:The dual effect of capsaicin on primary afferent neurons, excitation and stimulation of transmitter release, its dependence on extracellular calcium and its modulation by Ruthenium Red have been investigated in the rabbit ear. Injection of capsaicin into the central artery of the isolated perfused ear with intact neur...

journal_title：Neuroscience

authors： Amann R,Donnerer J,Lembeck F

更新日期：1989-01-01 00:00:00

abstract：:In situ hybridization histochemistry was used to localize calcitonin gene-related peptide mRNAs in spinal cord, brain stem and dorsal root ganglion neurons of the rat and guinea-pig. A 32P-labeled 23-base-long (23mer) oligodeoxyribonucleotide (oligomer) complementary to calcitonin gene-related peptide mRNA sequences e...

journal_title：Neuroscience

authors： Réthelyi M,Metz CB,Lund PK

更新日期：1989-01-01 00:00:00

abstract：:It has previously been found that, in the presence of naloxone, the ganglionic blocking drug hexamethonium fails to completely block peristaltic motility in the isolated ileum of the guinea-pig. This hexamethonium-resistant peristaltic activity is coordinated by enteric nerves since it is abolished by tetrodotoxin. In...

journal_title：Neuroscience

authors： Barthó L,Holzer P,Leander S,Lembeck F

更新日期：1989-01-01 00:00:00

abstract：:Rats were trained in a specially designed apparatus to detect brief, unpredictable visual stimuli presented to either side of the head. In one condition, rats reported the detection of the visual stimulus by removing their heads from a central location and responding in one of two adjacent side-holes where the visual ...

journal_title：Neuroscience

authors： Carli M,Jones GH,Robbins TW

更新日期：1989-01-01 00:00:00

abstract：:We have recently shown that isolated neuronal growth cones from developing rat forebrain possess an appreciable activity of adenylate cyclase, producing cyclic adenosine monophosphate, which can be stimulated by various neurotransmitter receptor agonists and by forskolin [Lockerbie R. O., Hervé D., Blanc G., Tassin J....

journal_title：Neuroscience

authors： Lockerbie RO,Autillo-Touati A,Araud D,Seite R,Chneiweiss H,Glowinski J,Prochiantz A

更新日期：1989-01-01 00:00:00

abstract：:Review of the normally occurring neuronal patterns of the hippocampus suggests that the two principal cell types of the hippocampus, the pyramidal neurons and granule cells, are maximally active during different behaviors. Granule cells reach their highest discharge rates during theta-concurrent exploratory activities...

journal_title：Neuroscience

authors： Buzsáki G

更新日期：1989-01-01 00:00:00

abstract：:In the dog cerebral cortex and spinal cord, [3H]bremazocine and [3H]U69593 both bound with high affinity to an apparent single population of binding sites under kappa-selective conditions. In the cortex similar Bmax values for both radioligands in the saturation studies and the high affinity of the kappa-selective age...

journal_title：Neuroscience

authors： Hunter JC,Birchmore B,Woodruff R,Hughes J

更新日期：1989-01-01 00:00:00

abstract：:The findings in this feline study indicate that the enkephalin-positive subcommissural part of the globus pallidus, which is known to contain GABA and cholinergic cells projecting to the cortex, is innervated by the anterodorsal region of the caudate nucleus, but not by the core. Like stimulation of a particular subcl...

journal_title：Neuroscience

authors： Cools AR,Spooren W,Bezemer R,Cuypers E,Jaspers R,Groenewegen H

更新日期：1989-01-01 00:00:00

abstract：:The course of the ascending pathways originating from the anterior gustatory and posterior visceral sensory part of the solitary tract nucleus and the topographic organization of the projections to the hypothalamus in the rat were studied with anterogradely transported Phaseolus vulgaris lectin. In general, the poster...

journal_title：Neuroscience

authors： Ter Horst GJ,de Boer P,Luiten PG,van Willigen JD

更新日期：1989-01-01 00:00:00

abstract：:Calcium permeabilities were examined in large cerebellar neurons maintained in culture, and morphologically identified as Purkinje cells. When cells were supplied with a Dulbecco Minimum Eagle's Medium with 10% horse serum added (5-10 days), somatic recordings revealed complex spikes and these were shown to be generat...

journal_title：Neuroscience

authors： Bossu JL,Dupont JL,Feltz A

更新日期：1989-01-01 00:00:00

abstract：:In IMR32 neuroblastoma cells, the two adenosine receptor agonists N6-R-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine dose-dependently stimulated membrane adenylate cyclase activity with potencies consistent with the presence of adenosine receptors of the A2-subtype. The S enantiomer of N6-R-phenylisoprop...

journal_title：Neuroscience

authors： Abbracchio MP,Cattabeni F,Clementi F,Sher E

更新日期：1989-01-01 00:00:00

abstract：:The cellular mechanisms underlying the genesis of thalamic ponto-geniculo-occipital waves were studied in reserpinized cats under urethane anaesthesia. Simultaneous field potential and intracellular recordings were performed in the lateral geniculate nucleus after acute lesions of retinal and visual cortical inputs. I...

journal_title：Neuroscience

authors： Hu B,Steriade M,Deschênes M

更新日期：1989-01-01 00:00:00

abstract：:The morphochemical disposition of the adenylate cyclase-linked dopamine receptor (D1 type) in the rat striatum has been assessed at various time points after a neurotoxic lesion of the dopaminergic afferent pathway to the caudate nucleus. D1 receptor binding sites in the caudate nucleus were determined by in vitro aut...

journal_title：Neuroscience

authors： Ariano MA

更新日期：1989-01-01 00:00:00

abstract：:The cellular components of striatal grafts into the host striatum of rats were studied using [3H]thymidine autoradiography, histochemistry, immunocytochemistry and Golgi-staining. Autoradiography revealed that a layer of glial cells, somas smaller than 8 microns in diameter, stained positive with glial fibrillary acid...

journal_title：Neuroscience

authors： Zhou FC,Buchwald N,Hull C,Towle A

更新日期：1989-01-01 00:00:00

abstract：:Explants of anterior, intermediate and posterior pituitary lobes of rats at various ages evoked an intense nerve fibre outgrowth when co-cultured with neonatal sympathetic superior cervical ganglia in a collagen gel medium. Freezing and thawing of pituitary lobes, prior to culture, did not abolish their growth-promoti...

journal_title：Neuroscience

authors： Lahtinen T,Soinila S,Lakshmanan J

更新日期：1989-01-01 00:00:00

abstract：:In cultured bovine adrenal medullary cells, neosurugatoxin and histrionicotoxin inhibited carbachol-induced influx of 22Na, 45Ca and secretion of catecholamines with IC50 of 27 nM and 3 microM, respectively. The inhibitory effects of neosurugatoxin were reversed by the increased concentrations of carbachol, whereas th...

journal_title：Neuroscience

authors： Wada A,Uezono Y,Arita M,Tsuji K,Yanagihara N,Kobayashi H,Izumi F

更新日期：1989-01-01 00:00:00

abstract：:Efferent projections of intrastriatally implanted striatal neurons have been studied using a combination of anterograde and retrograde axonal tracers. Adult rats subjected to a unilateral ibotenic acid lesion of the head of the caudate putamen received cell suspension grafts obtained from 14 15-day-old striatal primor...

journal_title：Neuroscience

authors： Wictorin K,Simerly RB,Isacson O,Swanson LW,Björklund A

更新日期：1989-01-01 00:00:00

abstract：:The existence of presynaptic muscarinic acetylcholine receptors on motor nerve terminals of the isolated frog sartorius muscle was investigated. The modulatory role of these receptors was studied by observing the effects of muscarinic ligands on the frequency of miniature endplate potentials and on the quantal content...

journal_title：Neuroscience

authors： Arenson MS

更新日期：1989-01-01 00:00:00

abstract：:Differences in the uptake of tracers from radioactive 2-deoxyglucose ([1,2-3H] and [2,6-3H]), and glucose ([1-3H], [3-3H]) into hippocampal regions were investigated by freeze-mount microautoradiography after 45 min for 2-deoxyglucose, and after 15 and 45 min for glucose. Silver grains were assessed quantitatively by ...

journal_title：Neuroscience

authors： Shimada M,Shimono R,Ozaki HS

更新日期：1989-01-01 00:00:00

abstract：:In the present study we have examined the topographic and temporal patterns of expression of the limbic system associated membrane protein by light and electron microscopic immunocytochemistry in organotypic cultures of the rat brain. The regional, cellular and subcellular distribution of staining in young cultures wa...

journal_title：Neuroscience

authors： Keller F,Levitt P

更新日期：1989-01-01 00:00:00

abstract：:Developmental alterations in GABAergic synaptic transmission were examined physiologically and biochemically in hippocampus of rats from 3 days of age to adulthood. Neither antidromic nor orthodromic stimulation could elicit identifiable inhibitory postsynaptic potentials in CA1 neurons in slices from rats 5 or 6 days...

journal_title：Neuroscience

authors： Swann JW,Brady RJ,Martin DL

更新日期：1989-01-01 00:00:00

abstract：:The purpose of the present study was to identify processes of plasticity in the receptive field of neurosecretory neurons of the supraoptic nucleus during hibernation in the hedgehog, in order to correlate them with the increased neurosecretory activity observed in this nucleus during this annual period. Using the Rap...

journal_title：Neuroscience

authors： Sanchez-Toscano F,Caminero AA,Machin C,Abella G

更新日期：1989-01-01 00:00:00

abstract：:Intracellular recordings were made from submucous plexus neurons of the guinea-pig cecum maintained in vitro. Histamine (0.3-10 microM) produced a dose-dependent membrane depolarization (congruent to 13 mV with 3 microM) in about 28% of the cells tested; most of these cells showed a prominent calcium-activated potassi...

journal_title：Neuroscience

authors： Tokimasa T,Akasu T

更新日期：1989-01-01 00:00:00

abstract：:The corticostriatal projection in rat neostriatal grafts was studied by using the axonal transport of Phaseolus vulgaris-leucoagglutinin. The neostriatal primodia from 15-18-day embryos were used to make a cell suspension which was implanted unilaterally into the rat neostriatum 3-5 days after kainic acid lesion. Two ...

journal_title：Neuroscience

authors： Xu ZC,Wilson CJ,Emson PC

更新日期：1989-01-01 00:00:00

abstract：:The anatomical distributions and affinity states of dopamine D1 and D2 receptors were compared in the rat central nervous system using quantitative autoradiography. [3H]SCH23390 and [3H]spiperone (in the presence of 100 nM mianserin) were used to label the D1 and D2 receptors, respectively. The densities of D1 and D2 ...

journal_title：Neuroscience

authors： Richfield EK,Penney JB,Young AB

更新日期：1989-01-01 00:00:00

abstract：:The involvement of the GABA-benzodiazepine receptor complex in the regulation of melanotropin secretion has been investigated using perfused frog neurointermediate lobes. The GABAA agonist 3-amino-1 propane sulfonic acid mimicked the biphasic effect of GABA on alpha-melanocyte-stimulating hormone secretion: a brief st...

journal_title：Neuroscience

authors： Tonon MC,Adjeroud S,Lamacz M,Louiset E,Danger JM,Desrues L,Cazin L,Nicolas P,Vaudry H

更新日期：1989-01-01 00:00:00

abstract：:A qualitative and quantitative immunohistochemical study of cholinergic systems in the human hippocampal formation was performed with an antibody against choline acetyltransferase. Four control subjects and six patients with Alzheimer's disease, matched for age and post-mortem delay, were examined. Immunoreactive nerv...

journal_title：Neuroscience

authors： Ransmayr G,Cervera P,Hirsch E,Ruberg M,Hersh LB,Duyckaerts C,Hauw JJ,Delumeau C,Agid Y

更新日期：1989-01-01 00:00:00

abstract：:Histochemical and immunohistochemical techniques were used to determine relationships between the parvalbumin or calbindin D28k content and the cytochrome oxidase or carbonic anhydrase activity of neurons in lumbar dorsal root ganglia in rat. Subpopulations of dorsal root ganglion neurons that displayed parvalbumin- o...

journal_title：Neuroscience

authors： Carr PA,Yamamoto T,Karmy G,Baimbridge KG,Nagy JI

更新日期：1989-01-01 00:00:00

abstract：:The polarization of neuronal trees by external point stimulation is modelled. In one form of model, an almost spheroidal field encloses the dendritic tree. Radially projecting, electrically linear dendrites, along with extracellular medium, are considered to occupy the entire field. The spheroid is modified by a penet...

journal_title：Neuroscience

authors： Hentall ID

更新日期：1989-01-01 00:00:00

abstract：:The borders of the ventral striatum and ventral pallidum of the rat brain have been studied with immunocytochemistry for two protein markers that are present in these regions. One of these, DARPP-32 (dopamine and cyclic AMP-regulated phosphoprotein, Mr 32,000), is specifically enriched in medium-sized spiny neurons of...

journal_title：Neuroscience

authors： Walaas SI,Ouimet CC

更新日期：1989-01-01 00:00:00

abstract：:The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...

journal_title：Neuroscience

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1989-01-01 00:00:00

abstract：:The effect of nerve growth factor on the intact versus injured septohippocampal cholinergic system of adult rats was studied. Nerve growth factor was continuously infused into the lateral ventricle of adult uninjured rats or rats that had received unilateral partial transection of the fimbria. Controls (operated and u...

journal_title：Neuroscience

authors： Fusco M,Oderfeld-Nowak B,Vantini G,Schiavo N,Gradkowska M,Zaremba M,Leon A

更新日期：1989-01-01 00:00:00